Sir Isaac Newton was a famous physicist, philosopher, mathematician, and astronomer, among other things. He has been referenced throughout the Arthur series:
- In "Francine Frensky, Superstar," it is revealed that Francine once played Newton in a play. The part is shown where she (as Newton) discovers gravity.
- In "Arthur's Treasure Hunt," Arthur imagined that Sir Isaac Newton's Father limited his scientific work when he was a child due to stop moping around and telling him to expect ideas to fall from the sky.
- Newton's cradle, an object named after Newton, has also appeared throughout the Arthur series, especially in "D.W. Beats All."