|"The Great MacGrady"|
|Number in season:||1|
|Original Airdate:|| October 19, 2009|
May 7, 2010
March 1, 2010 
|Written by:|| Peter K. Hirsch|
|Storyboard by:||Zhigang Wang|
"D.W.'s Furry Freak-out"
"The Silent Treatment"
When Mrs. MacGrady is diagnosed with cancer, Arthur and his friends all act differently to the news - Arthur and D.W. rush to her side with heaps of chicken soup and stuffed animals, Muffy tries to pretend that nothing in her life has changed, and Francine is so upset she can't even bring herself to visit Mrs. MacGrady.
Everyone loves Mrs. MacGrady, the school's cook for the cafeteria. One day, while Buster was keeping record for the school lunch and was making prediction for that day's lunch menu, he and his friends noticed that she did not show up for school, and her nephew is substitute chef. He is not a good cook and all the food became so bad that the students could not even eat it. After about a week without Mrs. MacGrady, Mr. Ratburn announces that she won't be returning for a while, because she has cancer.
Later that day, Francine and Muffy are at the Mill Creek Mall looking for a birthday present for Muffy's father Ed Crosswire. While looking at ties, Muffy asks Francine which tie she should get for her dad, but Francine ignores Muffy, and sadly sits in a chair. Muffy asks why Francine is being like that. Francine said she doesn't feel like shopping as she's still thinking about Mrs. McGrady having cancer, and informs Muffy that some people don't recover from the illness as her grandfather died from cancer. Francine returns home, after Muffy asked another question about her father's birthday gift.
Meanwhile, Arthur and D.W. make a house visit to Mrs. MacGrady, and bring her some home made chicken soup. D.W. asks Mrs. MacGrady why she has a bandanna over her head. Mrs. MacGrady tells her it's a scarf, and due to treatment, she has no hair, and must keep a special scarf on her head. She also assures a worried D.W. that cancer is not contagious. Arthur and D.W. stop by everyday and bring stuffs for Mrs. MacGrady.
During the soccer game, Francine was not feeling any better and let the opponent win the match, because of Mrs. MacGrady having cancer. Binky was surprised and told her about the game. She later left the soccer field angrily because she was so worried about Mrs. MacGrady and even refused to go to Muffy's Father's birthday dinner.
On Muffy's father's birthday, she gives him a card and tie. She tells him it would've been from Francine too, but she was too sad to help. Mr. Crosswire tells Muffy that Francine is just upset due to Mrs. MacGrady's illness. He also tells her that maybe she should go help Mrs. MacGrady around the house and bring her a care package.
Francine had a nightmare that night where she dreamt about Mrs. MacGrady leaving School after she picked up her stuff, saying that she is sick and needed an easier job. After she woke up, she decided to stay home for the day after her parents were worried about her and about her nightmare and after feeling worried about her.
While at home, she met Binky and Buster after school just right in front of her house where she was playing with her pet Nemo. Both asked her if she would like to visit Mrs. MacGrady's house, while they are also planning on bringing her some vegetables and a rock. Before they left and before Francine decided to visit her, Binky gave her Lance Armstrong's e-mail address, where he got it from Lance at the Bike-A-Thon. He told her the story about Lance where Lance had cancer and during Lance's time of race. Binky suggested her to write Lance an e-mail. She refused at first but decided to write to him and wrote him an e-mail in the end.
The next day at school, while the students still have complaints about the food at the cafeteria, Francine received the letter from Lance Armstrong. Her friends were surprised when they heard it. Muffy immediately went shopping after school with Francine for Francine's dress. Muffy asked Francine if she would like to visit Mrs. MacGrady. Francine refused and was afraid to visit her.
Arthur and D.W. arrived at Mrs. MacGrady's house and gave her more jars for soup and even a big fur bear. Muffy soon arrives and joined them. Just like D.W., Muffy also asked Mrs. MacGrady the same question on the first visit, about bandanna, after Arthur and D.W. left her house.
About a week later, Lance came to Francine's house and soon they went for a bike ride, after she changed into her normal clothes, while she was dressed up. While they were taking the rest during biking, he told her the stories about the time when he had cancer.
Francine decided to hold a bike race "Pedal for a cure" to raise money for cancer. Some of the other students helped too besides participating in a race, where Prunella is knitting a scarf for Mrs. MacGrady and George is helping out with the gardening. Francine had some help from her friends to spread out the word about the race and a lot of students signed up for it. After school, Muffy asked Francine if Francine would like to visit Mrs. MacGrady. Francine was still afraid to visit her and said that she still have more flyers to pass out.
When Muffy arrives at Mrs. MacGrady's house, Mrs. MacGrady introduce Muffy to her sister, Martha. While Muffy was still trying to clean dishes, Arthur and D.W. arrived. She later tells them that may be giving Mrs. MacGrady too many things. D.W. says that they're just trying to help. Muffy tells them that there is a different way they can help. The three clean Mrs. MacGrady's house and dishes. Before they left, they left the note for Mrs. MacGrady, before Mrs. MacGrady comes home.
On the race day, Lance Armstrong and Francine and the other bikers were at the starting line to race. Francine rides her bike really fast, down the race track, to the finish line, where Mrs. MacGrady is waiting for her. Francine apologizes for not coming to see her, and Mrs. MacGrady accepts her apology. She later has Francine wash her hands, and gives her a big hug.
More than a month later at school ever since Mrs. MacGrady was still absent, the lunch is still unpleasant to the children, even Buster complains. Mrs. MacGrady shows up and announces she still has cancer, but she's still getting treatment and feels better enough to return to work.
- Leah MacGrady
- Arthur Read
- D.W. Read
- Buster Baxter
- Francine Frensky
- Muffy Crosswire
- Binky Barnes
- Lance Armstrong
- Skip Bitterman
- James MacDonald
- Nigel Ratburn
- Ed Crosswire
- Alan Powers
- Catherine Frensky
- Oliver Frensky
- George Lundgren
- 3rd Grade Male Rat
- Laverne Frensky
- Millicent Crosswire
- Francis Haney
- 3rd Grade Male Dog (Number 3)
- Fern Walters
- Jenna Morgan
- Sue Ellen Armstrong
- Maria Pappas
- 3rd Grade Male Aardvark
- 3rd Grade Male Rabbit (Number 3)
- D.W. is wearing a surgical mask in this episode. Her brother Arthur wore one in "My Dad, the Garbage Man," "Hic or Treat," and "Vomitrocious" and her father wore one in "Operation D.W."
- In the beginning of the intro, a doppelganger of Mrs. Powers is seen walking in the hallway.
- This was Lance Armstrong's second appearance on Arthur.
- The episode was inspired by Leah Ryan, after she became diagnosed with cancer and it was later dedicated to her.
- There was a couple flashbacks from Arthur - It's Only Rock 'n' Roll.
- El Boomerang can be seen being kicked by a boy on a webcam.
- In the soccer game, Francine was goalie, although she is the star forward of the team.
- When D.W. is shoving the supposedly stuffed polar bear toy, Chilly Billy, through the doorway and drops him on the floor, he winces and closes his eyes as though he were alive.
- For a brief moment near the beginning of the second half of the episode, Marina is seen at a lunch table in the background. This is the second time that she appears due to an error, the other time also being in Season 13 in MacFrensky.
- In Francine's dream, Mrs. MacGrady was going to walk into light at the end of the hallway. This was decided to be "too much" for kids, so a green wall was placed over the light effects.
- Reruns of this episode are rare following the Lance Armstrong doping case.